Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.

The synthesis, SAR studies, and pharmacokinetic properties of oxadiazole based tubulin inhibitor class are reported. This class of compounds binds to the colchicine site on tubulin and has antimitotic activity with nanomolar potency against tumor cell lines including cells with MDR phenotype.