Production of offspring from a germline stem cell line derived from neonatal ovaries

Kang Zou,Zhe Yuan,Zhaojuan Yang,Huacheng Luo,Kejing Sun,Li Zhou,Jie Xiang,Lingjun Shi,Qingsheng Yu,Yong Zhang,Ruoyu Hou,Ji Wu

NATURE CELL BIOLOGY（2009）

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摘要

It has been controversial whether female germline stem cells (FGSCs) are present in postnatal mammalian ovaries. Cells from a line derived from FGSCs isolated from adult mice that were transplanted into ovaries of infertile animals underwent oogenesis and generated offspring.

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关键词

chromatin,polarity,adhesion,ageing,nature,biochemistry,stem cell,dna damage,signal transduction,zebrafish,biophysics,migration,cell biology,molecular biology,transcription,genetics,cytoskeleton,cell cycle,cancer,apoptosis,microrna,signalling,stem cells

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