Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering.
Journal of Bioscience and Bioengineering(2010)
摘要
Aspergillus oryzae penicillin biosynthetic genes were clustered. The penicillin production was positively regulated by VeA, a global gene regulator required for transcriptional expression of the penicillin biosynthetic genes. Overexpression of the biosynthetic genes by a strong promoter yielded a greater than 100-fold increase in penicillin production.
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关键词
Aspergillus oryzae,Secondary metabolism,Penicillin,VeA,Genetic engineering
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