Effet de la suppression androgénique par agonistes de la LH-RH sur les fonctions cognitives de patients atteints de cancer de prostate☆

Objective. - To evaluate secondary effects on cognitive functions as memory and attention impairments in men treated by androgen suppression for cancer of prostate. Material and methods. - A prospective study on men treated with luteinizing hormone-realising hormone analogues (LH-RH analogues) for cancer of prostate was designed. Eighteen men were evaluated with cognitive tests as Mini Mental State (MMS), memory evaluation (Grober-Buschke, Rey Test), attention and executive test (Trail Making Test and Montgomery Asberg Depression Rating Scale [MADRS]) before beginning androgen suppression. Base line pretreatment assessments of every patient were compared with similar tests after six and 12 months of hormone therapy. Results. - On 18 patients, 14 were eligible with pretreatment-median PSA of 22 ng/ml (13-659), testosterone of 477 ng/dl (398-583), which decreased to 1 and 37 ng/dl, respectively. Visual-memory test (Rey test) was significantly improved at M6 (p: 0,001) and M12 (p: 0,02) as was the inversed number-memory test (WAIS) after M6 of androgen suppression and (p: 0,03). Conclusion. - After 12 months of androgen suppression, global cognitive performances were preserved. Our results failed to observe impairment of cognitive function. This deserves more important prospective study. (C) 2008 Elsevier Masson SAS. Tous droits reserves.