Evaluation of potential MHC-I allele-specific epitopes in Zika virus proteins and the effects of mutations on peptide-MHC-I interaction studied using in silico approaches

•Potential epitopes are HLA allele specific.•Lys45 in B pock et of HLA B44 leads to selective binding of peptides with Glu at P2.•Asp at P1 of epitopes decrease the HLA B8 binding affinity and stability.•Mutation from Thr to Pro at P2 of the NS5 832 decrease the HLA A1 binding affinity.•The immunodominant peptide E 4 in mice has low HLA B 44 binding affinity.