Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex

    Bioorganic & medicinal chemistry letters, Volume 18, Issue 1, 2008, Pages 109-113.

    Cited by: 33|Bibtex|Views3|Links
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    Keywords:
    ironmetal ion

    Abstract:

    Inspired by the structures of natural nucleases, guanidinium groups were introduced into binuclear iron(III) systems. Compared with the corresponding analogue without guanidinium groups, the new diiron(III) system led to considerable rate enhancement on DNA cleavage. The cooperativity between metal ions and guanidine groups was evidenced ...More

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