Parallel Synthesis Of 3-Aryloxy-2-Propanolamines And Evaluation As Dual Affinity 5-Ht1a And 5-Ht Re-Uptake Ligands

Monique B. van Niel,Margaret S. Beer,JoséL. Castro,Susan K.F. Cheng,David C. Evans,Anne Heald,Laure Hitzel,Peter Hunt,Russell Mortishire-Smith,Desmond O'Connor,Alan P. Watt,Angus M. MacLeod

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1999）

引用 23|浏览17

暂无评分

摘要

A solution phase synthesis for the preparation of 3-aryloxy-2-propanolamine libraries has been developed. This resulted in the identification of 5 as a ligand with dual affinity for 5-HT1A and serotonin reuptake receptors which shows excellent pharmacokinetic parameters, (C) 1999 Elsevier Science Ltd. All rights reserved.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要