Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes.

Devasenan Devendra,Johanna Paronen,Edwin Liu,Hiroaki Moriyama,Robert Taylor,Dongmei Miao,Liping Yu,George Eisenbarth

ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION（2004）

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摘要

Insulin peptide B:9-23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.

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关键词

insulin,diabetes,Balb/c,autoantibody,poly IC

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