Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity
Bioorganic & Medicinal Chemistry Letters（2005）
摘要
Compound 28 was found to have a dissociated glucocorticoid profile in vitro and produced a dose-dependent anti-inflammatory response in an in vivo mouse model.
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关键词
Glucocorticoid,Dissociation,Transrepression,Transactivation,Inflammation
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