A dipyrido [2,3-b:3′,2′-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine

Alexey B. Dyatkin,Janice R. Brickwood,John R. Proudfoot

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

The syntheses of 11-ethyl and 11-cyclopropyldipyrido[2,3-b:3',2'-f]azepines analogs of the HIV-1 reverse transcriptase inhibitor nevirapine 1, are described. :These compounds exhibit potency equivalent to nevirapine in the inhibition of wild-type and some mutant RT enzymes. (C) 1998 Elsevier Science Ltd. All rights reserved.

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enzyme,wild type

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