Convenient preparation of N-8-quinolinyl benzenesultams as novel NF-κB inhibitors

Yuli Xie,Gangli Gong,Yidong Liu,Shixian Deng,Alison Rinderspacher,Lars Branden,Donald W. Landry

Tetrahedron Letters（2008）

引用 35|浏览13

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摘要

An efficient synthesis of a series of N-8-quinolinyl benzenesultams as novel NF-κB inhibitors was described via diazotization-induced cyclization of easily accessible N-8-quinolinyl-2-aminobenzenesulfonamides.

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关键词

Benzenesultam,NF-κB,Diazotization,Cyclization

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