2-(Anilinomethyl)imidazolines as α1A Adrenergic Receptor Agonists: 2′-Heteroaryl and 2′-Oxime Ether Series

A series of 2′-heteroaryl and 2′-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human α1A, α1B, and α1D receptor subtypes. Potent and selective α1A agonists have been identified in these series.