Biomarker modulation in a nonhuman rhesus primate model for ovarian cancer chemoprevention

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 10, Issue 8, 2001, Pages 889-893.

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    Keywords:
    phenotype

    Abstract:

    The objective of this study was to explore whether a nonhuman primate model could be developed to test drugs for the prevention of ovarian cancer.Nineteen adult female Rhesus macaques were given fenretinide (4HPR), oral contraceptives (OCP), the combination (4HPR + OCP), or no medication for 3 months. Exploratory laparotomy was done pre- ...More

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