Association Of Glucose Transporter 1 Polymorphisms With Type 2 Diabetes In The Tunisian Population

Background T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case-control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM.Research Design and Methods All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism.Conclusion The TAT haplotype of the GLUTI gene confers susceptibility to T2DM in the Tunisian population. Copyright (c) 2008 John Wiley & Sons, Ltd.