Clinical significance of expressions of EGFR,VEGF and Cbl in NSCLC tissues

OBJECTIVE:To investigate the expressions of EGFR,VEGF and Cbl in non-small cell lung cancer tissues and their relationships with the occurrence and pathological feature of NSCLC.METHODS:Total 110 cases of NSCLC tissues and 6 cases normal lung tissues adjacent to cancer tissues were collected from the hosipital,with which microtissue array were constructed.The immunohistochemistry SP methed was used to evaluate EGFR,VEGF and Cbl expressions in tumors,and normal lung cancer and their relationships with the pathological feature were studied.RESULTS:The positive rates of EGFR,VEGF and Cbl in 110 non-small cell lung cancer tissues were 58.2%(64/110),79.1%(87/110) and 31.8%(35/110) respectively.The expressions of EGFR and VEGF in NSCLC were significantly higher than those in normal lung tissues (P=0.007;P=0.03).The positive expression of Cbl was signifancantly higher in small size tumor (P=0.033).The expression of EGFR was correlated with VEGF positively (P0.01).The subgroup analysis showed that in the absence of lymph node metastasis,age 60 years old of the patients,Cbl had a positive correlation with VEGF (P0.05).The volume of tumor and lymph node metastasis were the independent factors of prognosis.CONCLUSIONS:EGFR,VEGF and Cbl are aberrant highly expressed in NSCLC with a positive correlation,which indicates they might act synergistically in angiogenesis of NSCLC,which may be related to the progression of lung cancer,but cannot predict prognosis of NSCLC patients.The correlation of Cbl and volume of tumor is due to the ubiquitination of tumor related protein,which can influence the volume of tumor and the process of tumor.