Fused heterocyclic M1 positive allosteric modulators

Scott D. Kuduk,Christina N. Di Marco,Victoria Cofre,William J. Ray,Lei Ma,Marion Wittmann,Matthew A. Seager,Kenneth A. Koeplinger,Charles D. Thompson,George D. Hartman,Mark T. Bilodeau

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

Fused aromatics such as naphthalene were identified as highly potent and CNS penetrant M1 positive allosteric modulators during an SAR study to replace the phenyl B-ring linkage.

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关键词

Muscarinic,Alzheimer’s,Allosteric modulator

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