Overexpression of CaMKIIδc in RyR2R4496C+/− Knock-In Mice Leads to Altered Intracellular Ca2+ Handling and Increased Mortality
Journal of the American College of Cardiology(2011)
摘要
Conclusions CaMKIIδc overexpression in RyR2 R4496C+/− knock-in mice increases the propensity toward triggered arrhythmias, which may impair survival. CaMKII contributes to further destabilization of a mutated RyR2 receptor.
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关键词
arrhythmias,CaMKIIδc overexpression,intracellular Ca2+ handling,mutated ryanodine receptors,sarcoplasmic reticulum Ca2+ leak
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