Discovery And Sar Of Para-Alkylthiophenoxyacetic Acids As Potent And Selective Ppar Delta Agonists

Bioorganic & Medicinal Chemistry Letters(2009)

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摘要
Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARd agonists. (C) 2009 Elsevier Ltd. All rights reserved.
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关键词
Selective PPAR delta agonists, Dyslipidemic, Achiral analogs
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