Genetic linkage analysis of bipolar affective disorder in an Old Order Amish pedigree

Human genetics, Volume 88, Issue 5, 1992, Pages 562-568.

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Keywords:
Variable Number Tandem Repeat Bipolar Affective Disorder Diagnostic Model Genetic Linkage Analysis Variable Band

Abstract:

We have used genetic linkage analysis in an effort to identify a gene responsible for bipolar affective disorder (BAD) in an Old Order Amish pedigree. The initial study of this pedigree showed strong evidence for linkage of the chromosome 11p15 markers HRAS1 and the insulin gene (INS) to BAD, whereas a second report found no evidence for ...More

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