DNA Repair Has a New FAN1 Club

In recent issues of Molecular Cell , Cell , and Science , Smogorzewska et al. (2010), MacKay et al. (2010), Kratz et al. (2010) , and Liu et al. (2010) identify FAN1 as a nuclease that is recruited to sites of interstrand crosslinks by ubiquitylated FANCD2, where it participates in DNA repair. The identification of FAN1 fills a missing link in interstrand crosslink DNA repair.