Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes.

Tomasz W. Glinka,Stephen E. de Laszlo,Peter K.S. Siegl,Raymond S. Chang,Salah D. Kivlighn,Terry S. Schorn,Kristie A. Faust,Tsing-Bau Chen,Gloria J. Zingaro,Victor J. Lotti,William J. Greenlee

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1994）

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摘要

The quinazolinone sulfonylcarbamate L-163,579 (9) is a potent, balanced antagonist of the binding of angiotensin II (Ang II) to human AT(1) and AT(2) receptors. This antagonist produces a long-lasting blockade of Ang II-induced presser response in both rats and dogs after oral administration.

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