Prediction of paclitaxel pharmacokinetic based on in vitro studies: interaction with membrane models and human serum albumin.

•PTX spontaneously partitions in fluid disordered and gel ordered membrane phases.•PTX fluidizes membrane and changes lipid packing parameters in the gel ordered phase.•PTX distorts the membrane polar region arrangement and interacts with the alkyl chains.•PTX-HSA binding retains over 90% of drug and causes changes in protein conformation.•Drug-membrane/HSA interactions are invaluable for in vitro pharmacokinetic profiling.