A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae.

Jian Zhang,Delphi Chatterjee,Patrick J Brennan,John S Spencer,Avraham Liav

Bioorganic & Medicinal Chemistry Letters（2010）

引用 14|浏览5

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摘要

The non-reducing disaccharide segment of phenolic glycolipid I from Mycobacterium leprae, O-(3,6-di-O-methyl-β-d-glucopyranosyl)-(1→4)-O-2,3-di-O-methyl-α-l-rhamnopyranose was synthesized by an improved procedure and efficiently conjugated to bovine/human serum albumin.

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关键词

Leprosy,PGL-I,Natural disaccharide,Neoglycoprotein,Serological activities

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