RIG-I "sees" the 5'-triphosphate.

Structure（2010）

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摘要

RIG-I protects host cells against various RNA viruses by sensing viral RNAs in the cytoplasm. Crystal structures of RIG-I C-terminal domain bound to 5'-triphosphate dsRNA unveils how RIG-I recognizes the 5'-triphosphate moiety, a hallmark of viral RNAs (Lu et al., 2010).

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