Analysis for the Influence of Obstructive Sleep Apnea Syndrome on Peripheral and Central Blood Pressure in Male Patients

Objective: To analyze the influence of obstructive sleep apnea syndrome(OSAS) on peripheral and central blood pressure in male patients.Methods: There were 54 consecutive male patients for OSAS screening in our hospital were enrolled in this study,all patients without antihypertensive medication.Peripheral and central blood pressure,brachial-ankle pulse wave velocity(ba-PWV) were measured at sitting position before OSAS monitoring in all patients.According to apnea hypopnea index(AHI),the patients were divided into 2 groups as Control group,AHI5,n=20,andOSASgroup,AHI≥5,n=34.Theageandbodymassindex(BMI)weresimilarbetweentwogroups.Results: Compared with Control group,OSAS group presented significantly increased central arterial pressure,peripheral blood pressure and ba-PWV,P0.05~0.01.In OSAS patients,the central systolic blood pressure(CSBP) and peripheral systolic blood pressure(PSBP) were closely related;peripheral diastolic blood pressure(PDBP) and ba-PWV were closely correlated,P0.05.BaPWV obviously related to age and PSBP,P0.05.Taking CSBP as response variable,the multiple regression analysis,including the age,BMI,AHI,oxygen desaturation index(ODI),lowest SaO2 and ba-PWV revealed that ba-PWV was a significant contributor for increased CSBP in OSAS,P=0.014.In addition,taking ba-PWV as response variable,the multiple regression analysis,including AHI,ODI,lowest SaO2,age,BMI,PSBP and PDBP revealed that ODI was a significant contributor to affect ba-PWV,P=0.032.Conclusion: Peripheral blood pressure,CSBP and the arterial stiffness were all higher in OSAS patients.Elevated CSBP might be associated with the increased arterial stiffness.