Echinomycin, a bis-intercalating agent, induces C→T mutations via cytosine deamination

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, pp. 291-300, 1993.

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Keywords:
induction ofc→t and tandem cc→tt mutationslacz α-complementation reversion assaycytosine deaminationechinomycin

Abstract:

Echinomycin, a bis-intercalating, antitumor drug, has been studied for its ability to induce the deamination of cytosine to uracil (C→U) in double-stranded DNA. We have employed a sensitive lacZ α-complementation reversion assay to detect G·C→A·T mutations at a number of sites in M13mp2 DNA to determine the extent to which distortions of ...More

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