Discovery Of Cp-199,330 And Cp-199,331: Two Potent And Orally Efficacious Cysteinyl Lt1 Receptor Antagonists Devoid Of Liver Toxicity

Robert J Chambers,Anthony Marfat,G.W. Antognoli,John B Cheng,David B Damon,A.V. Kuperman,T.C. Liston,C. Mebus,J.S. Pillar,J.T. Shirley,J.W. Watson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1999）

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摘要

CP-199,330 (3) and CP-199,331 (4) are cysLT(1) receptor antagonists that are equipotent to marketed cysLT(1) receptor antagonists zafirlukast and pranlukast, show good pharmacokinetics in rats and monkeys, and are devoid of liver toxicity in monkeys as seen in CP-85,958 (1). (C) 1999 Elsevier Science Ltd. All rights reserved.

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