Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.

Haolun Jin,Sammy Metobo,Salman Jabri,Michael Mish,Rachael Lansdown,Xiaowu Chen,Manuel Tsiang,Matthew Wright,Choung U Kim

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

SAR studies on the para-fluorobenzyl moiety of tricyclic HIV integrase inhibitors are discussed and lead compounds with potency and PK properties comparable to raltegravir were identified.

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关键词

AIDS,HIV,Integrase inhibitor,Tricyclic,Benzyl moiety

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