Chiral synthesis of C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3)

TETRAHEDRON（1999）

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摘要

Enantioselective alkylation of chiral amide enolates derived From L-prolinol with beta-branched chiral iodides afforded good yields of hydroxy amide adducts. which were elaborated in four steps to give C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3). (C) 1999 Elsevier Science Ltd. All rights reserved.

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关键词

asymmetric synthesis,enantioselection,alkylation,enolates,peptide analogues mimetics

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