Lewis acid assisted cyclization of arylcyanoguanidines to 2,4-diaminoquinazolines
JOURNAL OF HETEROCYCLIC CHEMISTRY(1994)
摘要
The mild preparation of N-cyano-N'-(1-H-indol-5-yl)guanidine and its cyclization to 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline is described. Whereas previously reported methods of cyclization employed high temperatures to effect ring closure, we found that certain Lewis acids, such as boron trifluoride etherate, induce cyclization at moderate temperatures.
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