Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies
Leukemia Research(2010)
摘要
Mutations in the BLM gene cause human Bloom syndrome (BS), an autosomal recessive disorder of growth retardation, immunodeficiency and cancer predisposition. Homozygous null Blmm3/m3 mice are cancer prone with a 5-fold increased risk of cancer compared with Blmm3/+ and Blm+/+ mice. Irradiation of Blmm3/m3 mice increased the risk to 28-fold. Tumors occurred mainly in the hematopoietic system and were similar to those in BS based on detailed histologic and immunohistochemical analyses. Irradiated Blm-deficient mice thus provide a novel model for understanding accelerated malignancies in BS and a new platform for investigating the molecular basis for a wide range of hematopoietic neoplasms.
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关键词
Bloom syndrome,Blm-deficient mouse model,Histopathology,Immunohistochemistry,Mouse lymphoma,Mouse leukemia,Tissue microarray
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