Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands
Bioorganic & Medicinal Chemistry Letters（2007）
摘要
A several series of low molecular weight 5-HT2A leads were identified from an analysis of HTS data, the exploration of SAR and optimisation one series using parallel synthesis is described affording compound 22 (5-HT2A IC50 1.1nM).
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关键词
5HT2A,Antagonist,Library,High-throughput,Screening,Synthesis
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