Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor

Amy S. Antipas,Laura C. Blumberg,William H. Brissette,Matthew F. Brown,Jeffrey M. Casavant,Jonathan L. Doty,James Driscoll,Thomas M. Harris,Christopher S. Jones,Sandra P. McCurdy,Eric McElroy,Mark Mitton-Fry,Michael J. Munchhof,David A. Reim,Lawrence A. Reiter,Sharon L. Ripp,Andrei Shavnya,Marc I. Smeets,Kristen A. Trevena

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

5-F substitution of an aminothiazole moiety within a series of thrombopoietin receptor agonists leads to potent agents with an improved hepatic safety profile in rodent toxicology studies.

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关键词

TPO,Thrombopoietin,Agonist

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