Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

The synthesis of the potent and selective h-11-β-HSD-1 inhibitor 11 (Ki=8nm) is reported.

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关键词

11-β-HSD-1 inhibitors,Adamantane,Multicomponent reaction,Metabolism,HSD1 inhibitor,Hydroxysteroid dehydrogenase type 1,Metabolic syndrome

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