Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells

Umashankar Das,Alireza Doroudi,H. Inci Gul,Hari N. Pati,Masami Kawase,Hiroshi Sakagami,Qing Chu,James P. Stables,Jonathan R. Dimmock

Bioorganic & Medicinal Chemistry（2010）

引用 21|浏览7

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摘要

A number of 2-benzylidene-6-(nitrobenzylidene)cyclohexanones emerged as lead compounds which possess noteworthy cytotoxicity, selective toxicity towards neoplasms than non-malignant cells and well tolerated in mice in short-term toxicity studies.

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关键词

Unsaturated ketones,Selective cytotoxicity,Structure–activity relationships,Murine toxicity

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