Raman Spectroscopy: A Strategic Tool in the Process Analytical Technology Toolbox

An overview of the role and use of Raman spectroscopy for advanced process measurements is presented. Special emphasis is given to the potential of Raman spectroscopy as a tool for assessment, monitoring and advanced control of chemical content and crystallinity/polymorphism during pharmaceutical processing. As a Process Analytical Technology (PAT) tool, Raman spectroscopy can add value to both product/process development and to manufacturing processing. The wide range of PAT examples that are reviewed in this chapter emanates from emerging applications in primary and secondary manufacturing processing and in bioprocessing. In addition, strategies and the special requirements on Raman instrumentation for PAT are discussed.