The enantioselective synthesis and antiinflammatory activity of novel aryl-sphingolipid PKC inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1995)
摘要
Recently we identified three promising topically active antiinflammatory agents (2, 3, and 4) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementioned leads and their comparative biological profile. The individual enantiomers examined are equipotent to their racemate in vitro and in vivo.
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关键词
protein kinase c
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