Effect of nifedipine administration on the functional capacity of neutrophils
Molecular and cellular biochemistry(1993)
摘要
Administration of nifedipine to mice over a period of six months caused a significant (p<0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation.
更多查看译文
关键词
neutrophils,nifedipine,superoxide,chemotaxis,phagocytosis,NADPH
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要