A Practical Synthesis of Lithium 3-Fluoropyridine-2-carboxylate
SYNTHETIC COMMUNICATIONS(2004)
摘要
A practical and efficient method for the preparation of lithium 3-fluoropyridine-2-carboxylate as well as its four regioisomer is described. 3-Fluoropyridine can be regioselectively lithiated on C-2 or C-4 depending on the reaction conditions. A quench procedure with carbon dioxide was developed which conveniently provides the lithium carboxylate in high yield and purity.
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关键词
carbon dioxide,carboxylation
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