Potent, Nonpeptidic Oxytocin Receptor Antagonists From A Natural Source

Gino M. Salituro,Douglas J. Pettibone,Bradley V. Clineschmidt,Joanne M. Williamson,Deborah L. Zink

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1993）

引用 31|浏览23

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摘要

Penicillide, a previously described natural product, and several related compounds have been discovered to be antagonists of the peptide hormone oxytocin. A few simple derivatives of the compound were isolated and/or synthesized and its absolute stereochemistry was determined.

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