correlação entre cOX-2 e ciclina D-1 após administração de tamoxifeno neoadjuvante em curto prazo no tratamento de carcinoma de mama Correlation of COX-2 and ciclyn D-1 after short-time neoadjuvant tamoxifen on breast cancer

Introduction: Tamoxifen is the most used drug in the hormonal therapy of the breast cancer. Ciclyn D-1, one CCND1 gene product's (PRAD1), is essential for the normal lobule-alveolar mammary development and acts in the cellular cycle control. Ciclyn D-1 superexpression act negatively in tamoxifen treatment,