Mathematical Models Of Human Iodine Metabolism, Including Assessment Of Human Total Body Iodine Content

As soon as radioactive tracers of iodine, especially iodide, thyroxine (T4), and triiodothyronine (T3), became available after the end of World War II, research began on the kinetics of radioiodine in humans, as well as in experimental animals. As measuring devices improved, radioactivity could be measured not only in the blood plasma, but also in other body fluids, and external measurement of the radioactivity in the thyroid and in other organs of the body soon became feasible. A rich body of experimental data ensued; there was a need to synthesize these data into a unifying theoretical structure.