A nano β-TCP/gelatin/velvet antler polypeptide bone graft substitutes for rabbit mandibular defect repair

This study was designed to evaluate the effect of Nano β-TCP/Gelatin/Velvet Antler Polypeptide(Nano β-TCP /Gelatin/VAP) bone graft substitutes on the reparative capacity in rabbit mandible defect.In this study,the clinical result,macrography observation and histological evaluation are presented on 80 consecutively treated rabbits. They were divided into four groups:material group 1(containing 5 mg/g of VAP),material group 2(containing 20 mg/g of VAP),material group 3(no VAP) and control group(blank).Samples were harvested according to the schedule(four groups):five animnls after 2,4,8 and 12 weeks respectively,and the implants were harvested for macrography observation,histological and SEM analysis.These suggest that the Nano β-TCP/Gelatin in combination with VAP provide a viable therapeutic alternative for implant placement.The Nano β-TCP/Gelatin/VAP materials may promote bone formation in rabbit mandible area.And the groupl resulted in a higher quality and quantity of new bone formation was than the other three groups in 4 weeks.The defect of control group was filled by the adipose tissue, blood vessels,fibrous connective tissue and irregular bone trabeculae which is not continuous.Both groups were no obvious necrosis and inflammatory cell infiltration in the region of defect.The Nano β-TCP/Gelatin/Velvet Antler Polypeptide(Nano β-TCP/Gelatin/VAP) bone graft substitutes possesses the manifest reparative capacity in rabbit mandible defect.