The effects of prenatal exposure to delta-9-tetrahydrocannabinol on the rest-activity cycle of the preweanling rat

Either 15 or 50 mg/kg of delta-9-tetrahydrocannabinol (delta-9-THC) was administered from Day 2 through Day 22 of gestation. Pair-fed (0 mg/kg) and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether delta-9-THC produces effects on the rest-activity cycle of the offspring, groups of 3 littermates from each of the treated and control groups were tested for an 8 hr observation period on electronic activity monitors at 17, 22 and 30 days of age. Whereas all treated and control groups showed age-dependent changes in activity, neither activity level nor the rest-activity pattern were affected by delta-9-THC. These findings are discussed in relation to neurobehavioral studies of activity changes following prenatal exposure to cannabis.