Reactivity of PNA Thioesters in Chemical Ligation Reactions

Martijn C. de Koning,Matthijs van der Knaap,Lene Petersen,Hans van den Elst,Gijsbert A. van der Marel,Mark Overhand,Dmitri V. Filippov

SYNLETT（2005）

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摘要

The ligation rate and efficiency of PNA thioesters in the reaction with the pentapeptide CRYNK has been determined and proved to be substantially lower in comparison with the corresponding C-terminal glycine thioester.

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关键词

native chemical ligation,thioesters,peptide nucleic acid,reactivity,convergent synthesis

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