Tricyclic thienopyridine–pyrimidones/thienopyrimidine–pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain

Bioorganic & Medicinal Chemistry Letters(2009)

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摘要
A series of highly potent and selective mGluR1 antagonists have been discovered and demonstrated efficacy in animal model for pain.
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关键词
Tricyclic thienopyridine–pyrimidone,Thienopyrimidine–pyrimidone,Triazafluorenone,mGluR1 antagonist,Neuropathic pain
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