P1‐095: Characterization of brain region‐ and disease‐specific IDE expression in Alzheimer patients and controls

2.6 (95% CI: 1.2-5.2), and one copy with a risk ratio of 1.9 (95% CI: 1.1-3.4). Moreover, two adjacent SNPs, rs6163 and rs743572, had similar genotype risk ratios as rs10786712, suggesting that the region flanking rs10786712 may harbor risk variants. Conclusions: We report that the variants at CYP17 decrease age at onset and increase the likelihood of AD in high risk women with DS, independent of BMI, ethnicity, level of intellectual disability, and APOE. We are currently examining the relation between risk SNPs and multiple sex hormone levels to further understand this association.