Novel Tricyclic Benzothiazolo[2,3-c]thiadiazine Antagonists of the Platelet ADP Receptor (P2Y12)

Robert M. Scarborough,Alan M. Laibelman,Lane A. Clizbe,Larry J. Fretto,Pamela B. Conley,Elwood E. Reynolds,David M. Sedlock,Hans-Michael Jantzen

Bioorganic & Medicinal Chemistry Letters（2001）

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摘要

Novel non-nucleoside tricyclic platelet ADP receptor (P2Y12) antagonists have been discovered that bind reversibly and with high affinity to the platelet receptor. Condensation of various 2-aminobenzothiazoles with chlorosulfonylacetyl chloride affords these novel tricyclic heterocycles, which are novel and unpredicted products of this reaction.

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