Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.

Ariamala Gopalsamy,Hui Yang,John W. Ellingboe,Hwei-Ru Tsou,Nan Zhang,Erick Honores,Dennis Powell,Miriam Miranda,John P. McGinnis,Sridhar K. Rabindran

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

A novel series of anti-proliferative agents containing a pyrazolo[1,5-a]pyrimidine scaffold and the structure–activity relationship studies to improve potency are described.

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关键词

Pyrazolopyrimidine,Anti-proliferative agents,Anti-cancer agents,Parallel synthesis

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