Trasplante de Progenitores Hematopoyéticos en Pediatría: 10 Años de Experiencia

ABSTRACT Hematopoietic Stem Cell Transplantation in Pediatrics: 10 years experience Background: In Uruguay the survival estimates for pediatric patients with cancer are comparable to those in developed countries. With the aim of improving outcomes in patients with worse prognosis and provide therapeutic options for treating some non malignant diseases, we started a hematopoietic stem cell transplan-tation (HSCT) program in 1997, with the fi nancial support of the National Resources Fund (Fondo Nacional de Recursos-FNR). Patients and Methods: The unit was created at the Asociacion Espanola Hospital and counts with three rooms with a sophisticated isolation system. Isolation measures and guidelines for preven-ting opportunistic infections were strictly enforced. HSCT indications followed the national FNR guidelines according to recommendations of international groups. International standards were used for the patients ma-nagement. Results: In 10 years 131 transplants were performed in 129 patients. The 10 year overall survival estimate was 43.9 ± 4.6%. Transplant related mortality was 9.3% and the main cause of death was infections. In allogenic HSCT acute graft